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[9] [10] Common adverse effects include gastrointestinal symptoms such as nausea, vomiting, diarrhea, and constipation, which typically diminish with continued use

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Results are typically long-lasting when weight remains stable, but significant weight gain can affect outcomes over time

Clinical studies, including long-term trials (up to four years of oral supplementation), have found that ALA has a strong safety profile with no significant adverse effects at usual doses