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A recent trial comparing tirzepatide to semaglutide showed a greater increase in weight loss after a year, with losses of 15.3% with tirzepatide compared with 8.3% for semaglutide

For multiple comparisons, one-way ANOVA followed by Tukeys post hoc test was used

While these medications are generally well tolerated, gastrointestinal side effects such as nausea and constipation are common and have been reported to limit therapy [2, 3, 4]

There is no significant changes in the degree of tolerance along with GGT and MDA levels [163]

Side Effects That May Show Up Early Some patients may experience side effects as their body adjusts to GLP-1 therapy, including: Nausea Bloating Fatigue Headache Constipation These symptoms may improve over time for some patients, but duration varies

Some patients report faster or slower weight loss, while others notice different patterns of appetite suppression