GLP-1 drugs have obviously been all the rage for weight loss, and there has been some off-label use of them to treat liver disease like MASH, but in the Phase III ESSENCE trial, after 72 weeks, 63% of patients on Wegovy saw their steatohepatitis resolved without any worsening of fibrosis, compared to just 34% with placebo
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It results in sustained release through binding to serum albumin
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If lifts are declining consistently over several weeks despite adequate sleep and recovery, lean mass loss is the probable cause
Similarly, in the class IIIII obesity subgroup (BMI 35.0 kg/m), live birth rates were 9.4% in the semaglutide group compared with 16.6% in controls (OR = 0.52, 95% CI 0.340.80, p = 0.0024)