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No patient developed lactic acidosis during a follow up period of 26.8 months.37 Although these studies did not report the glycemic effects, it is likely that better glycemic control was a contributor to reduced morbidity and mortality

The effect of the medication is temporary and completely reversible once the medication is stopped

Suspected side effects should be reported via the MHRA Yellow Card Scheme (yellowcard.mhra.gov.uk)

Understanding the FDAs black box warning Black box warnings, issued by the FDA, indicate the major risks associated with the medication

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The safety profile under long-term exposure outside a supervised clinical context remains undetermined