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Based on the phase 2 and phase 3 trial protocols: Weeks 1-4: 1 mg once weekly Weeks 5-8: 2 mg once weekly Weeks 9-12: 4 mg once weekly Weeks 13-16: 8 mg once weekly Weeks 17 onward: 12 mg once weekly (maximum dose) The starting dose of retatrutide is deliberately low because the triple-agonist mechanism produces more intense initial side effects than single-pathway compounds
Women with irregular cycles or chronic anovulation might experience more regular egg release due to this impact
The same study found that people taking Wegovy were more likely than those in the placebo group to lose 5, 10, 15, or 20% of their starting weight
Nutrition: Keep protein intake adequate and overall diet balanced to support metabolism and lean mass
Woolston CM, Al-Attar A, Storr SJ, Ellis IO, Morgan DA, Martin SG