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Role of ketogenic diets in neurodegenerative diseases (Alzheimers disease and Parkinsons disease)

It actively degrades through specific enzymatic processes

Obese individuals often exhibit both elevated NNMT in adipose tissue and impaired muscle regenerative capacity a connection that NNMTs dual tissue effects could help explain

It is particularly notable that clearance of senescent cells prevents tau-dependent pathology and cognitive decline in neurodegeneration

Given the FoxO1 ablation induced -cell dedifferentiation and caused hyperglycemia under physiologic stress 22 , we determined whether LOsG/ROS stresses decrease FoxO1 expression and thus induce -cell dedifferentiation