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Similarly, those reporting occasional cravings rose from 3.6% (14 participants) to 8.7% (34 participants)

Mechanistically, this may represent a protective adaptation to avoid lipotoxic stress: saturated fatty acids, such as palmitic acid, are highly toxic in LCLs, and continuous de novo synthesis under hypoxia would exacerbate this burden

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Short-acting formulations reach peak plasma concentrations within 1-3.5 hours and have shorter elimination half-lives, while long-acting agents like semaglutide have half-lives of approximately one week, allowing for sustained therapeutic effects

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