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Vitamin B12 deficiency is a common problem, specially among older adults and vegetarians

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Knockout mutants of odc were arrested in the Y-form and were unable to undergo the Y-H transition [110]

It doesn't seem to be tissue-specific

Other symptoms include those listed below, which generally begin around the time of menopause, worsen after menopause, persist throughout older age, and can have a significant negative effect on quality of life