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GLP-1 receptor agonists have been used successfully and safely in type 2 diabetes mellitus (T2DM) and do not induce insulin desensitization after prolonged use, as they do not activate insulin receptors in normoglycemic subjects [16] and thus do not cause hypoglycemia

Clustering of GLP-1R agonist fingerprints correlates with ADRs The experiments described above provided a rationale for extending our investigation of transducer engagement to compartments beyond the plasma membrane