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It can be taken at any time of the day, with or without meals

Thus, the results of earlier studies [16, 18, 19], which have relied on exendin(939)amide being specific for only the GLP-1 receptor, should be interpreted with caution, especially with respect to the relative contribution of GLP-1 to the enteroinsular axis

Cell pellets (~2030 l of packed cell pellet) were re-suspended in 1 ml buffer containing 20 mM HEPES (pH = 7.5), 10 mM KCl, 250 mM sucrose, 5 mM MgCl 2 , 1 mM EGTA, 1x phosphatase inhibitor cocktail (Sigma, P0044) and 1x protease inhibitor cocktail (Sigma, P8340), and lysed by addition of digitonin (Sigma, D141), 200 g/ml final concentration at 4 C for 10 min

Nat Rev Mol Cell Biol 8: 813824

This study investigated the effectiveness of the GLP-1 agonist SEMA in reducing diabetic neuropathic pain in a streptozotocin-induced diabetic rat model

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