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Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology

When present, side effects are typically mild and transient, potentially including slight drowsiness if administered too early (easily resolved by timing adjustment), mild headaches during initial adaptation in some individuals (usually resolving within days), temporary vivid dreams as sleep architecture normalizes, or rare reports of mild dizziness upon waking in sensitive individuals

Nat Rev Cardiol 22 , 551563 (2025)

Apply 4 sprays twice a day to a clean, non-hairy area such as the abdomen, then rub in for 60 to 90 seconds

The studies consistently reflected effects as tissue protection, inflammation control, and vascular stability

PMID: 27517151