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Glia 2 : 420436 Galvan V, Logvinova A, Sperandio S, Ichijo H and Bredesen DE (2003) Type 1 insulin-like growth factor receptor (IGF-IR) signaling inhibits apoptosis signal-regulating kinase 1 (ASK1)

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Elevated levels of IL-21 and altered TFH/TPH activity are strongly associated with the severity of SLE ( T-cell: Autoreactive T cells are pivotal in the pathogenesis of SLE, as they regulate immune activation, inflammation, and target cell cytotoxicity