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reported in approximately 4060% of participants in higher-dose groups Vomiting reported in approximately 2030% of participants at higher doses Diarrhoea Constipation Decreased appetite (which, whilst contributing to weight loss, can also be uncomfortable) The majority of gastrointestinal events were mild to moderate in severity and tended to diminish over time as participants adjusted to the medication

Theyve been criticized for what critics say is a lack of transparency about the rebates they receive and for keeping a large portion of cost savings from consumers

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