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These two factors are intertwined and together form the pathophysiological basis for the development of complications

A 2015 study found that colloidal oatmeal lotion had antioxidant and anti-inflammatory properties

Where the component evidence is strongest and weakest GHK-Cu is the best-characterized of the four, with a substantial mechanistic and topical-skincare literature behind it which makes it a reasonable anchor to build a blend around

The mechanism was suggested to occur at a post-transcriptional or translational step of collagen biosynthesis, though this remains to be confirmed

PMID: 38383406 Proc Natl Acad Sci U S A Mitochondrial ROS triggers mitophagy through activating the DNA damage response signaling pathway

That tradeoff is unavoidable with incretin-based therapies