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La American Diabetes Association (ADA) recomienda los agonistas GLP-1 con beneficio cardiovascular demostrado (como liraglutida, semaglutida inyectable y dulaglutida) para pacientes con enfermedad cardiovascular establecida o alto riesgo cardiovascular, independientemente del uso de metformina

However, for many people, this drug is too expensive and unavailable due to a variety of reasons

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For example, researchers have found that GSH levels are low in patients with diabetic retinopathy 12 where glutathione synthesis is reduced and in problems of the vitreous

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the AAs had produced a fourfold increased glucagon secretion through increasing action potential firing with resultant opening of VGCCs [49] (Fig