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Tirzepatide, marketed as Mounjaro for type 2 diabetes and Zepbound for weight management, is a dual GIP and GLP-1 receptor agonist that has transformed metabolic treatment

While prevention is paramount, this growing mechanistic framework raises hypotheses for future studies that targeting mitochondrial metabolism can open windows of epigenetic plasticity toward more positive health outcomes, particularly in subjects with a history of adverse childhood experiences

Secondary endpoints were change in (1) quantitative sensory testing

This knowledge helps set realistic expectations about what blood tests reveal and why ongoing monitoring remains essential during Ozempic treatment

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