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3.3 Melanin-synthesis-inhibiting peptides of mushrooms and bacteria In a 1974 study, a peptide (Madhosingh and Sundberg, 1974) with tyrosinase inhibitory activity was first reported

Additionally, another transcription factor, AP-1 (activating protein-1) is significantly involved in the cellular stress response of melanocytes

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Furthermore, the pH environment of rosacea skin is often disrupted