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Drug-associated parosmia: New perspectives from the WHO safety database
It is known that two highly conserved polar networks at the cytoplasmic face of class B1 GPCRs, the HETY network (H 2.50b E 3.50b T 6.42b Y 7.57b ) and the cytoplasmic polar network (R 2.46b R 6.37b N 7.61b E 8.49b ), lock the base of the receptor in a closed conformation 19
Treating it as a series of isolated problems produces, at best, partial solutions
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