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Expectedly, GPR120 agonism shows powerful anti-diabetic, anorexic, and hepatoprotective properties in multiple animal models (275, 284287), at least partially mediated by GLP-1 (288)

Researchers noted multiple study limitations, including use of records from health care organizations within the federated health research network TriNetX that may not be nationally representative, they wrote

Both drug classes affect appetite signaling and cardiovascular hemodynamics, requiring careful provider assessment before initiation

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