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PP1/PP2A phosphatases are required for the second step of Pre-mRNA splicing and target specific snRNP proteins

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Research has shown that 7,8-dihydroxyflavone (7,8-DHF) can alleviate SZ-like symptoms by effectively mimicing the effect of brain-derived neurotrophic factor (BDNF) in the brain (Jaehne et al., 2021) to selectively activate tyrosine kinase receptor B (TrkB) (Emili et al., 2022) and downstream Phospholipase C (PLC), AKT, and ERK1/2 signaling pathways

Moreover, diabetics often have reduced activity of enzymes and precursors needed for glutathione synthesis, worsening the deficiency

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