Clinical Uses Vitamin B12 injections are used to treat or prevent B12 deficiency in various situations: Pernicious anemia: An autoimmune condition where gastric intrinsic factor is missing
2015, pp
Cyanocobalamin is indicated for vitamin B12 deficiencies due to malabsorption which may be associated with the following conditions: Addisonian (pernicious) anemia Gastrointestinal pathology, dysfunction, or surgery, including gluten enteropathy or sprue, small bowel bacteria overgrowth, total or partial gastrectomy Fish tapeworm infestation Malignancy of pancreas or bowel Folic acid deficiency It may be possible to treat the underlying disease by surgical correction of anatomic lesions leading to small bowel bacterial overgrowth, expulsion of fish tapeworm, discontinuation of drugs leading to vitamin malabsorption (see Drug Interactions), use of a gluten-free diet in nontropical sprue, or administration of antibiotics in tropical sprue
doi:10.1002/jimd.12009
Conversely, pernicious anemia resulting from vitamin B12 deficiency may cause infertility or poor pregnancy outcomes
suggested a difference in the individual MTHFR gene variation ( In contrast to the aforementioned study ( Importantly, we did not preselect patients based on a positive response to previous vitamin B12 injections, leading to more generalizable results in our study
