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While GLP-1 receptor agonists like semaglutide address appetite suppression, and dual GLP-1/GIP agents like tirzepatide add insulin sensitization, retatrutide adds a third mechanism glucagon receptor activation that directly stimulates hepatic lipolysis and increases energy expenditure

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Contrave combines naltrexone, an opioid antagonist, and bupropion, an antidepressant that also helps with smoking cessation

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