The dose is usually increased every 4 weeks until the maintenance dose is reached: Weeks 1 to 4: 0.25mg once weekly Weeks 5 to 8: 0.5mg once weekly Weeks 9 to 12: 1.0mg once weekly Weeks 13 to 16: 1.7mg once weekly Week 17 and onwards: 2.4mg once weekly (maintenance dose) Your treatment provider may adjust this schedule depending on how well you tolerate the medicine
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If a single large meal consistently precedes pain, split it into two smaller plates and delay fiber-dense or high-fat items to later in the day while you adapt
Introduce high-fiber foods gradually over 23 weeks, and always pair them with adequate hydration to help fiber move through your digestive tract
Whats different by week 16 that wasnt true at week 6: Clothing size changes become noticeable, often one full size down The week 4-style plateaus become less frequent as the body adjusts to a stable dose Most patients have moved to 1mg by this point, which comes with a higher chance of GI side effects if the increase happened too quickly This is typically when patients start asking whether long-term medication or a surgical option makes more sense for their remaining weight loss goals If your 6-week results were on the lower end of the range and youre projecting out to 16 weeks, its worth talking to your prescriber about whether your current trajectory will realistically get you to your goal weight, or whether its time to discuss alternatives
Regular check-ins with PlexusDx's clinical team help track progress, adjust expectations based on your individual curve, and troubleshoot any side effects that might impact adherence
