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PMC 20490

5A, as concentrations of RSL3 higher than 1 M further induced cell death), and under these conditions, IRE1 deficiency would increase cystine uptake and GSH level through SLC7A11 and GCLC upregulation, mitigating the effects of GPX4 inhibition by RSL3

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Results: Incubation of cells with DHA doubled DHA, not EPA content in the membranes, and incubation with EPA increased both fatty acids content compared to control