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[3] It could have efficacy in preventing the development of nitrate tolerance

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The benzyl alcohol preservative has been linked to severe toxicity in this population, including a potentially fatal condition known as gasping syndrome. Newborns have immature metabolic pathways and cannot efficiently metabolize benzyl alcohol, leading to its accumulation and metabolic acidosis with respiratory failure in severe cases

60 We utilized a variational Bayesian approach for calibrating perfusion parameters and assessing the goodness of fit, employing the Bayesian Inference for Arterial Spin Labeling (BASIL) tool ( 61 This process generated calibrated images, which were then quantified into absolute CBF maps using a single compartment model, as detailed in prior research

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