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The meta-analysis of 10 randomized trials testing the effect of folic acid supplementation showed a significant reduction in CIMT in subjects with chronic kidney diseases and in those at risk for CVD, but not in healthy participants (107)

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In a 16-week randomized controlled trial in 92 subjects with type 2 diabetes and blood lipid abnormalities, participants took 500 mg green tea extract three times daily

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Given the high disease burden of NASH and limited therapeutic options currently available, the FDA has proposed an accelerated pathway for drug approval

This makes DSIP particularly relevant in experimental designs focused on integrated pathway behavior rather than isolated mechanisms such as receptor activation or gene expression control