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Note the date if this is the first time it has been outside the fridge

Most experts recommend long-term or indefinite use, transitioning to a maintenance dose rather than stopping completely, combined with sustained lifestyle changes

Thyroid Concerns Semaglutide carries a boxed warning about thyroid C-cell tumors based on animal studies

Many patients photograph their pen with the date to avoid confusion about when the 28-day window expires

While expired semaglutide with reduced potency is less likely to cause hypoglycemia, individual responses vary

However, because both can affect blood sugar, you must be careful about the risk of hypoglycemia and consult your provider before combining them