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Psychiatry 98 StanciuA.Zamfir-Chiru-AntonA.StanciuM.StoianA.JingaV.NitipirC.et al (2019)

Although most studies suggest that GLP-1RAs promote weight loss mainly due to their inhibitory effect on food intake, other central effects that have been described for native GLP-1 and some GLP-1RAs in rodents and humans encourage future clinical trials to explore additional mechanisms that potentially underlie the beneficial effects observed with this drug class

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As yet, the relationships between enzymatic activity and mutation of MTHFR have been reported in general healthy and mental retardation populations as well as in animals, no studies have been found in clinical test of MTHFR activity in psychiatric patients 88,89,90

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