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When insulin sensitivity improved through exercise or bariatric surgery, NNMT levels in adipose tissue fell suggesting NNMT activity tracks with metabolic state rather than being a passive marker

Tracking: Log the date, site used, and any observations (redness, soreness, lumps)

At 5-15 mg/mL concentration, even the highest documented weekly doses (15 mg tirzepatide, 12 mg retatrutide) draw under 1 mL

5-Amino-1MQ appeared to work by increasing the energy expenditure of the fat cells themselves