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NICE Clinical Knowledge Summaries and British Society for Haematology guidelines emphasise the importance of prompt investigation when clinical features suggest deficiency

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Regarding Spitzoid melanoma diagnosis, a recent description of five new histopathologic subtypes of Spitzoid melanomagenuine, uniform, packed, polypoid, and pigmentedaims to provide useful parameters to improve diagnostic confidence [49]

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However, if youve missed two or more consecutive doses, youll need to restart the treatment according to the dose escalation schedule

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