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One area of interest is musculoskeletal injuries, including muscle and tendon injuries

As described above for PABA/NO, JS-K, and GSNO, the NHGs, in accordance with GT expression patterns, contribute to chemotherapy by producing locally high levels of NO which can rapidly react with O 2 - to generate the potent oxidant peroxynitrite that, in turn causes extensive cellular damage, including the nitration of protein tyrosine residues (Kirsch et al., 2001)

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10.1016/j.biocel.2012.11.022 39

3.4 Reactive oxygen species (ROS) and antioxidants in cancer chemoresistance Cancer chemoresistance is a significant challenge in oncology, referring to the ability of cancer cells to survive and proliferate despite chemotherapy [75]