AGEs may also promote vascular dysfunction by reducing the bioavailability of nitric oxide (NO) and inhibiting endothelial NO synthase and antioxidant defense mechanisms 13,14
This is also supported with the finding that deficiency of nuclear factor-erythroid 2-related factor 2 (Nrf2), a master regulator of antioxidant defense responses including glutathione synthesis, had no effect on GSSSG-mediated inhibition of LPS-induced proinflammatory gene upregulation 33
S., Page, A
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I decided to augment the therapy with a topical glutathione cream and oral tart cherry extract, which is known to ameliorate exertional muscle pain and fatigue, but has not yet been specifically linked to relief of painful sickling crises
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