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In conclusion, MNs/GLP-1RAs@NPs-WYRGRL could increase the expression of GLP-1R, inhibit the cGAS-STING signaling pathway, suppress ferroptosis in chondrocytes of articular cartilage, and promote the expression of chondrocyte-related mechanisms such as ACAN and COL2
At the 6-month mark, the high-dose group saw a 3035% increase in mean glutathione levels within erythrocytes (red blood cells), plasma, and lymphocytes, and a massive 260% increase in buccal cells
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