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[2] [3] GLP-1 medications reduced major adverse cardiovascular events by 20% in the SELECT trial, with benefits extending beyond weight loss alone

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The peptide also induces the expression of vascular endothelial growth factor (VEGF) and angiopoietin-1, promoting angiogenesis in injured tissues

Their efficacy is assessed through in vitro (e.g., DPPH, FRAP), in situ, ex vivo, and in vivo models, as well as animal and human clinical trials, each offering unique advantages but facing challenges in standardization and physiological relevance

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