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Thus, we propose that SFN mediates activation of this molecular switch, and that restoration of the Nrf2/Prdx6 pathway provides a proof of concept that SFN can be considered as a therapeutic chemo-protectant to repair and reverse age-related diseases, such as cataractogenesis

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Although eumelanin can provide some protective effects against UV-induced damage, pheomelanin may exacerbate ROS production, leading to further oxidative stress and DNA damage in melanocytes, particularly under UV exposure 118