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Ghezzi, 2011

However, the mechanism of action of glutamine in the immune cells of cancer patients remains unclear, and further research is needed on the inhibitors of glutamine metabolism and their mechanisms of action, as well as the potential broader application of combined immune checkpoint inhibitors

D., Dong, M

Dis., 146:109-115 (1992)

GSH depletion studies: using a laboratory inhibitor such as buthionine sulfoximine (BSO) and confirming the result by direct GSH measurement

Abstract Glutamine (Gln) metabolism serves dual metabolic roles: it fuels the tricarboxylic acid (TCA) cycle, while concurrently sustaining redox balance through glutathione (GSH) synthesis