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The findings included: 63 % of patients had resolution of inflammation without worsened fibrosis (vs 34 % in the placebo group) 37 % had decreased fibrosis (vs 22 % in placebo) On average, patients lost more than 10 % of their weight This strengthens the view of GLP-1 agonists as much more than just weight loss, they impact central risk factors for long-term health
The criteria for participation were: amenorrhea for 6+ months and not pregnant normal development no markers of metabolic disease weight stable for the last 12 months (noted that subjects were 5-9% below ideal weight) normal adrenal and thyroid hormones Patients were divided into two groups 10 patients with LH less than 3 IU/mL (average of 0.9 +/- 0.1) and 10 with LH greater than 3 IU/mL (average of 7.1 +/- 1.5)
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After the subjects fasted overnight for 10 h, intravenous catheters were inserted into the superficial veins of both arms, one for continuous infusion of the tracer solutions and the other for repeated blood sampling
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