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doi: 10.1016/j.nutres.2022.03.002

FOXO4-DRI, a novel peptide-based intervention, specifically disrupts the interaction between FOXO4 and P53, thereby inducing apoptosis in senescent cells

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The peptide functions through multiple biological pathways to support tissue repair and regeneration

Moreover, riboflavin pathway derivatives, such as 5-(2-oxopropylideneamino)-6-d-ribitylaminouracil (5-OP-RU), 5-(2-oxoethylideneamino)-6-D-ribitylaminouracil (5-OE-RU) and 6,7-Dimethyl-8-(1-D-ribityl)lumazine (RL-6,7-diME), function as evolutionarily conserved non-peptidic antigens to a subpopulation of innate-like T cells, Mucosal Associated Invariant T (MAIT) cells, particularly enriched at mucosal surfaces of mammals, such as the gut, bronchea, skin and uterus 187,188,189

Lung Res