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As a widely used platinum-based chemotherapeutic, cisplatin frequently causes dose-limiting emotional disturbances

One such signaling route that seems to be engaged is the adenylyl cyclase pathway, potentially leading to the transformation of ATP (adenosine triphosphate) into cAMP (cyclic adenosine monophosphate)

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It is synthesized in the liver and kidneys from the amino acids lysine and methionine and is essential for transporting fatty acids into the mitochondria of cells

10.3892/ijo.2021.5272 Int

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