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Based on the conversion rate between rats and humans (6.17:1) [27], the daily intake of each prescription in rats were calculated and has been showed in Table S1

Systematic re-evaluation of the bis(2-hydroxyethyl)disulfide (HEDS) assay reveals an alternative mechanism and activity of glutaredoxins

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(3) Add 18.015 Da for the terminal water molecule (H at N-terminus + OH at C-terminus)

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Therefore, the two crucial mechanisms are that the transduction of PAR polymer to mitochondrial and the transfer of AIF from mitochondrial to nucleus to degrade chromatin