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The drug has transformed our ability to manage obesity and type 2 diabetes, and has shown potential for a wide range of conditions such as Alzheimer's, addiction and depression

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Publication bias and GRADE assessment As per the guidelines, a public bias assessment was not conducted for this study due to the limited number of included studies

Of note, to reduce the generation of mitochondrial ROS or to increase the scavenge of ROS similarly attenuate mitochondrial oxidative stress and kidney injury ( 3.2.1 Keap1-Nrf2-ARE signaling pathway activators 3.2.1.1 Epigallocatechin 3-Gallate (EGCG) EGCG, a bioactive constituent extracted from green tea, is widely investigated in various diseases, such as cardiovascular diseases, diabetes and cancer