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There are similar studies showing that arhalofenate acid activates AMPK in macrophages in vitro , inhibits the activation of NLRP3 inflammasomes, and reduces MSU-induced IL-1 production ( Colchicine can inhibit the release of IL-1-induced MSU crystal deposition joints

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The AnglV analog D-Nle-Tyr-Ile-NH-(CH 2 ) s -CONH 2 has a much longer circulating half- life than Norleual (Nle-Tyr-Leu-i^CHj-NH^-His-Pro-Phe (SEQ ID NO: 1)) As anticipated from the in- vitro blood stability data, D-Nle-Tyr-Ile-NH-(CH 2 )5- CONH 2 exhibited an extended in vivo elimination half-life of 1012 min after IV injection in rats

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