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However, conflicting findings and gaps in understanding persist, calling for further research into the mechanisms underlying the influence of DPP-4 on bone metabolism

Ann Intern Med 169(7):467473 Yoon KS, Strycharz JP, Baek JH, Sun W, Kim JH, Kang JS, et al

Semaglutide activates only GLP-1 receptors, while tirzepatide activates both GLP-1 and GIP receptors

1 rounded teaspoon up to 3 times per day

These findings require replication

the rationale is based on the fact that improved glycemia restores sensitivity to GIP [14, 16] and peptide engineering enables the design of hybrid ligands exhibiting dual agonism, as proved in experimental studies [19]