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In this model, tumors develop sequentially in mice carrying the transgene, initiating as non-angiogenic clusters of dysplastic cells, of which a proportion later develop to small angiogenic tumor islets that can progress to large vascularized tumors that metastasize to the lung

Psychiatry 14 , 90 (2024)

The synergistic or antagonistic effects of combined compounds must be thoroughly investigated, often requiring preliminary studies to establish safety and efficacy profiles

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That aligns nicely with the 30 mg total