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A key mechanism involves the transforming growth factor-beta (TGF-) signaling pathway

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Others who choose to take pills or subdermal supplements may notice a more gradual effect, sometimes taking a few weeks before their symptoms improve

Indeed, hormone influence over BDNF expression has been demonstrated in gonadectomized female and male rats, showing decreased BDNF mRNA levels in the hippocampus that can be rescued after estradiol supplementation (Singh et al., 1995