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The proposed mechanisms by which GLP-1 receptor agonists affect substance use include altering dopamine release in the brains reward centers, impacting the hypothalamic-pituitary-adrenal (HPA) axis and modulating stress-related pathways, Stanford said

Tirzepatide yielded the largest decrease among currently approved dual agonists, with an average weight loss of 20.9% at 72 weeks

The absence of randomized controlled trials means long-term organ impact, hormonal effects, and contraindications remain undocumented

Mental health support may also serve as a way for users to manage the feelings of being judged for using GLP-1s

NHS treatment is also covered for symptomatic recurrent mucocoeles and confirmed actinic cheilitis with progression risk

A recent study published in MDPI investigated L-theanine's ability to protect against subchronic neuroinflammation induced by lipopolysaccharide (LPS)