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KPV has been studied in cell and animal models related to intestinal inflammation, but it should not be viewed as a proven treatment for Crohns disease, ulcerative colitis, or other inflammatory bowel diseases

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Subsequently, whole exome sequencing (WES) of simplex families with one affected child demonstrated strong association of rare de novo exonic single nucleotide variants (SNV) with ASD [20,21,22,23,24], with more recent analyses highlighting around a hundred genome-wide significant ASD risk genes [25, 26]

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