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VPA is extensively metabolized by the liver via glucuronic acid conjugation, mitochondrial and cytosolic (endoplasmic reticulum) -oxidation to produce multiple metabolites, some of which may be biologically active (Fig

Finally, exendin-4-induced activation of both WT and V229A GLP-1R tended to reduce the diffusion of lipids at the plasma membrane labelled with the environmentally sensitive Laurdan probe (34) (Figure 4D), with no differences in Laurdan lateral diffusion between WT and V229A

The weight management clinics segment is expected to experience the fastest growth during the forecast period

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Diabetes Care 16(Suppl 3):155165