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whether (pro)drugs or nanocarriers reaches the target site in the brain (extra- or intracellular) and releases the parent drug at the target site at the adequate concentration to produce pharmacological effect

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F1000Research, 9, F1000 Faculty Rev-239

Diurnal fluctuation and pharmacological alteration of mouse organ glutathione content

23 The oxidation pathway begins with aminotransferase-mediated deamination and transfers the amino group to alpha-ketoglutaric acid to form glutamate to enter the urea cycle

However, it should be noted that ligands could not be easily separated from the transferrin receptor and the internalization by endo/lysosomes also compromised the detaching