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3.2.3 Sex hormones abnormalities Many research has discovered sex differences in the prevalence of both GD and depression, with a reported male-to-female ratio of 1:4-6 in GD and a ratio of roughly 1:2 in major depressive disorder (122, 128, 129)

GLP-1 receptor agonists like semaglutide are designed to mimic this effect, which is a primary reason they are effective for weight loss

Treatment is typically long-term

Among these, glucagon-like peptide-1 receptor agonists (GLP1RAs) have attracted particular attention for their profound effects on body weight, glycemic control, and cardiovascular outcomes [4,5] , which extend beyond metabolic effects [4] , alongside emerging evidence of liver-specific benefits [5,6]

Further research may be warranted to better understand the underlying factors and how response differs between males and females